Effects of lonomycin A on canine cardiac action potentials
نویسندگان
چکیده
منابع مشابه
Extracellular potentials related to intracellular action potentials during impulse conduction in anisotropic canine cardiac muscle.
This paper considers a quantitative description of intracellular and transmembrane currents in anisotropic muscle, with emphasis on the factors that determine the extracellular potentials. Although Vmax of the intracellular action potential had no relation to changes in conduction velocity in anisotropic tissue with constant membrane properties, the extracellular waveforms were quite sensitive ...
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We examined the effects of quinidine (5-20 microM) on transmembrane action potentials and ionic currents of isolated canine ventricular myocytes. Collagenase treatment of canine ventricular tissue produced a yield of 40-60% healthy cells. Myocytes had normal resting and action potentials as measured using conventional microelectrodes. Quinidine decreased Vmax, amplitude, overshoot, and the dura...
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15 صفحه اولSimulation of Cardiac Action Potentials Background Information
The goal of assignments related to this document is to experiment with a numerical simulation of the cardiac action potential. The form of this simulation is just as described in class, using the Hodgkin-Huxley formalism and differential equations to reproduce the currents responsible for the action potential. To simulate the cardiac action potential, it is necessary to expand the number of cha...
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(1.1) Cm ∂V ∂t = 1 Ra ∂2V ∂x2 − Iion(V, t)− Istim(t), where Ra and Cm are the axial resistance and membrane capacitance, Iion represents the total ionic current, and Istim(t) is an applied stimulus current which instigates an action potential. The source term Iion is usually specified by some Hodgkin-Huxley type ionic model. In our simulations, we use the Luo-Rudy phase I (1991) model, one of t...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1982
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)54057-4